Construct · 1 fields · 1 citations

3/75 rule: a standalone construct

One name. One construct. A landmark on the map.

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Drug discovery

finding that compounds with high lipophilicity and low polar surface area are more likely to cause adverse outcomes in animal toxicology studies.

In drug discovery, 3/75 rule refers to finding that compounds with high lipophilicity and low polar surface area are more likely to cause adverse outcomes in animal toxicology studies. This meaning comes from Hughes (2008) in Bioorganic & Medicinal Chemistry Letters.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cause3 fields · 7 citationsjingle · one word, three constructs surface3 fields · 3 citationsjingle · one word, three constructs topological polar surface area1 fields · 1 citationsanchor · a standalone construct

References

Hughes, J. D., Blagg, J., Price, D. A., Bailey, S., DeCrescenzo, G. A., Devraj, R. V., Ellsworth, E., Fobian, Y. M., Gibbs, M. E., Gilles, R. W., Greene, N., Huang, E., Krieger-Burke, T., Loesel, J., Wager, T., Whiteley, L., & Zhang, Y. (2008). Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorganic & Medicinal Chemistry Letters, 18(17), 4872-4875. https://doi.org/10.1016/j.bmcl.2008.07.071

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