Construct · 1 fields · 1 citations

altered peptide repertoire model: a standalone construct

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Clinical immunology

a mechanism of drug hypersensitivity in which a drug binds an HLA groove and changes which self-peptides are presented, provoking T cell attack.

In clinical immunology, altered peptide repertoire model refers to a mechanism of drug hypersensitivity in which a drug binds an HLA groove and changes which self-peptides are presented, provoking T cell attack. This meaning comes from Illing (2012) in Nature.[1]

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Nearby constructs

attack4 fields · 10 citationsjingle · one word, four constructs cell2 fields · 3 citationsjingle · one word, two constructs groove1 fields · 1 citationsanchor · a standalone construct

References

Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., Burrows, S. R., Purcell, A. W., Rossjohn, J., & McCluskey, J. (2012). Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature, 486(7404), 554-558. https://doi.org/10.1038/nature11147

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