Construct · 1 fields · 1 citations

antibody humanization: a standalone construct

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Immunology

moving the binding loops of a rodent antibody onto a human framework to lower immune reaction in patients.

In immunology, antibody humanization refers to moving the binding loops of a rodent antibody onto a human framework to lower immune reaction in patients. This meaning comes from Jones (1986) in Nature.[1]

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs reaction4 fields · 4 citationsjingle · one word, four constructs

References

Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. (1986). Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature, 321(6069), 522-525. https://doi.org/10.1038/321522a0

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