Construct · 1 fields · 1 citations

ApoE cascade hypothesis: a standalone construct

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ApoE cascadehypothesis1 CONSTRUCTApoE cascade hypothesisMARTENS · DEMENTIA RESEARCH

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Dementia research

the proposal that differences in apolipoprotein E structure set off a cascade of cellular and systemic changes that shape risk for Alzheimer's disease and related dementias.

In dementia research, ApoE cascade hypothesis refers to the proposal that differences in apolipoprotein E structure set off a cascade of cellular and systemic changes that shape risk for Alzheimer's disease and related dementias. This meaning comes from Martens (2022) in Neuron.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cascade4 fields · 4 citationsjingle · one word, four constructshypothesis2 fields · 2 citationsjingle · one word, two constructsrisk6 fields · 13 citationsjingle · one name, six constructs

References

  1. Martens, Y. A., Zhao, N., Liu, C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M., & Bu, G. (2022). ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias. Neuron, 110(8), 1304-1317. https://doi.org/10.1016/j.neuron.2022.03.004

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