Construct · 1 fields · 1 citations

bitopic ligand: a standalone construct

One name. One construct. A landmark on the map.

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Pharmacology

single molecule built to engage both the orthosteric site and an allosteric site of a receptor at once, aiming to combine affinity with selectivity.

In pharmacology, bitopic ligand refers to single molecule built to engage both the orthosteric site and an allosteric site of a receptor at once, aiming to combine affinity with selectivity. This meaning comes from Valant (2012) in Annual Review of Pharmacology and Toxicology.[1]

Unit
Recovery means
Measured by

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Nearby constructs

affinity3 fields · 4 citationsjingle · one word, three constructs ligand2 fields · 2 citationsinvariant · one construct, two systems receptor2 fields · 2 citationsjingle · one word, two constructs

References

Valant, C., Robert Lane, J., Sexton, P. M., & Christopoulos, A. (2012). The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein–Coupled Receptors. Annual Review of Pharmacology and Toxicology, 52(1), 153-178. https://doi.org/10.1146/annurev-pharmtox-010611-134514

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