Construct · 1 fields · 1 citations

central tolerance: a standalone construct

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Immunology

the removal of self-reactive T cells while they mature in the thymus, so that the surviving repertoire largely ignores self antigens.

In immunology, central tolerance refers to the removal of self-reactive T cells while they mature in the thymus, so that the surviving repertoire largely ignores self antigens. This meaning comes from Kappler (1987) in Cell.[1]

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs repertoire5 fields · 6 citationsjingle · one word, five constructs superantigen1 fields · 1 citationsanchor · a standalone immunology construct

References

Kappler, J. W., Roehm, N., & Marrack, P. (1987). T cell tolerance by clonal elimination in the thymus. Cell, 49(2), 273-280. https://doi.org/10.1016/0092-8674(87)90568-x

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