Construct · 1 fields · 1 citations

chemogenetic receptor: a standalone construct

One name. One construct. A landmark on the map.

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Neuroscience methods

receptor engineered to ignore natural ligands and respond only to an inert drug, used to switch cell activity.

In neuroscience methods, chemogenetic receptor refers to receptor engineered to ignore natural ligands and respond only to an inert drug, used to switch cell activity. This meaning comes from Armbruster (2007) in Proceedings of the National Academy of Sciences.[1]

Unit
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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs natural3 fields · 7 citationsjingle · one word, three constructs receptor2 fields · 2 citationsjingle · one word, two constructs

References

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007). Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proceedings of the National Academy of Sciences, 104(12), 5163-5168. https://doi.org/10.1073/pnas.0700293104

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