Construct · 1 fields · 1 citations

chimeric antigen receptor T cell: a standalone construct

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Biotechnology

a T cell given an engineered surface receptor that joins an antibody-derived binding domain to signalling parts.

In biotechnology, chimeric antigen receptor T cell refers to a T cell given an engineered surface receptor that joins an antibody-derived binding domain to signalling parts. This meaning comes from Eshhar (1993) in Proceedings of the National Academy of Sciences.[1]

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs cell2 fields · 3 citationsjingle · one word, two constructs chimera2 fields · 4 citationsjingle · one word, two constructs

References

Eshhar, Z., Waks, T., Gross, G., & Schindler, D. G. (1993). Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proceedings of the National Academy of Sciences, 90(2), 720-724. https://doi.org/10.1073/pnas.90.2.720

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