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clonal abortion: a standalone construct

One name. One construct. A landmark on the map.

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clonalabortion1 CONSTRUCTClonal abortionNOSSAL · IMMUNOLOGY

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Immunology

the proposal that immature B cells meeting antigen are aborted or silenced, deleting self-reactive clones before they mature.

In immunology, clonal abortion refers to the proposal that immature B cells meeting antigen are aborted or silenced, deleting self-reactive clones before they mature. This meaning comes from Nossal (1975) in The Journal of experimental medicine.[1]

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References

  1. Nossal, G. J., & Pike, B. L. (1975). Evidence for the clonal abortion theory of B-lymphocyte tolerance. The Journal of experimental medicine, 141(4), 904-917. https://doi.org/10.1084/jem.141.4.904

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