Construct · 1 fields · 1 citations

colloidal aggregation: a standalone construct

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Medicinal chemistry

mechanism in which screening compounds form colloids that nonspecifically sequester enzymes, producing false inhibition in biochemical assays.

In medicinal chemistry, colloidal aggregation refers to mechanism in which screening compounds form colloids that nonspecifically sequester enzymes, producing false inhibition in biochemical assays. This meaning comes from McGovern (2002) in Journal of Medicinal Chemistry.[1]

Unit
Recovery means
Measured by

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Nearby constructs

coagulation3 fields · 5 citationsjingle · one word, three constructs form4 fields · 7 citationsjingle · one word, four constructs inhibition4 fields · 4 citationsjingle · one word, four suppressions

References

McGovern, S. L., Caselli, E., Grigorieff, N., & Shoichet, B. K. (2002). A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening. Journal of Medicinal Chemistry, 45(8), 1712-1722. https://doi.org/10.1021/jm010533y

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