Construct · 1 fields · 1 citations

dark chemical matter: a standalone construct

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dark chemicalmatter1 CONSTRUCTDark chemical matterWASSERMANN · MEDICINAL

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Medicinal chemistry

screening-library compounds that stay inactive across hundreds of assays, proposed as clean starting points with low promiscuity.

In medicinal chemistry, dark chemical matter refers to screening-library compounds that stay inactive across hundreds of assays, proposed as clean starting points with low promiscuity. This meaning comes from Wassermann (2015) in Nature Chemical Biology.[1]

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Nearby constructs

matter2 fields · 3 citationsjingle · one word, two constructs

References

  1. Wassermann, A. M., Lounkine, E., Hoepfner, D., Le Goff, G., King, F. J., Studer, C., Peltier, J. M., Grippo, M. L., Prindle, V., Tao, J., Schuffenhauer, A., Wallace, I. M., Chen, S., Krastel, P., Cobos-Correa, A., Parker, C. N., Davies, J. W., & Glick, M. (2015). Dark chemical matter as a promising starting point for drug lead discovery. Nature Chemical Biology, 11(12), 958-966. https://doi.org/10.1038/nchembio.1936

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