Construct · 1 fields · 1 citations

deuterium switch: a standalone construct

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Medicinal chemistry

replacing hydrogen with deuterium at metabolically labile sites so the kinetic isotope effect slows metabolism and alters a drug's profile.

In medicinal chemistry, deuterium switch refers to replacing hydrogen with deuterium at metabolically labile sites so the kinetic isotope effect slows metabolism and alters a drug's profile. This meaning comes from Gant (2013) in Journal of Medicinal Chemistry.[1]

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Nearby constructs

isotope effect1 fields · 1 citationsanchor · a standalone construct kinetic isotope effect1 fields · 1 citationsanchor · a standalone construct labile3 fields · 3 citationsjingle · one word, three carriers

References

Gant, T. G. (2013). Using Deuterium in Drug Discovery: Leaving the Label in the Drug. Journal of Medicinal Chemistry, 57(9), 3595-3611. https://doi.org/10.1021/jm4007998

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