Construct · 1 fields · 1 citations

dihydropyrimidine dehydrogenase deficiency: a standalone construct

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dihydropyrimidinedehydrogenase deficiency1 CONSTRUCTDihydropyrimidineDIASIO · PHARMACOGENOMICS

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Pharmacogenomics

inherited low activity of the enzyme that breaks down pyrimidines, which causes severe toxicity from fluoropyrimidine drugs.

In pharmacogenomics, dihydropyrimidine dehydrogenase deficiency refers to inherited low activity of the enzyme that breaks down pyrimidines, which causes severe toxicity from fluoropyrimidine drugs. This meaning comes from Diasio (1988) in Journal of Clinical Investigation.[1]

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pharmacogenomics1 fields · 1 citationsanchor · a standalone construct

References

  1. Diasio, R. B., Beavers, T. L., & Carpenter, J. T. (1988). Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. Journal of Clinical Investigation, 81(1), 47-51. https://doi.org/10.1172/jci113308

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