Construct · 1 fields · 1 citations

extrachromosomal rDNA circle hypothesis of aging: a standalone construct

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Biology of aging

the hypothesis that self-replicating circles of ribosomal DNA accumulate in yeast mother cells and cause their replicative aging.

In biology of aging, extrachromosomal rDNA circle hypothesis of aging refers to the hypothesis that self-replicating circles of ribosomal DNA accumulate in yeast mother cells and cause their replicative aging. This meaning comes from Sinclair (1997) in Cell.[1]

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Nearby constructs

aging4 fields · 5 citationsjingle · one word, four constructs cause3 fields · 7 citationsjingle · one word, three constructs cell2 fields · 3 citationsjingle · one word, two constructs

References

Sinclair, D. A., & Guarente, L. (1997). Extrachromosomal rDNA Circles: A Cause of Aging in Yeast. Cell, 91(7), 1033-1042. https://doi.org/10.1016/s0092-8674(00)80493-6

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