Construct · 1 fields · 1 citations

fragment-based drug discovery: a standalone construct

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Medicinal chemistry

strategy that finds very small, weakly binding molecular fragments and links or grows them into potent ligands.

In medicinal chemistry, fragment-based drug discovery refers to strategy that finds very small, weakly binding molecular fragments and links or grows them into potent ligands. This meaning comes from Shuker (1996) in Science.[1]

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs strategy4 fields · 4 citationsjingle · one word, four constructs

References

Shuker, S. B., Hajduk, P. J., Meadows, R. P., & Fesik, S. W. (1996). Discovering High-Affinity Ligands for Proteins: SAR by NMR. Science, 274(5292), 1531-1534. https://doi.org/10.1126/science.274.5292.1531

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