Construct · 1 fields · 1 citations

frequent hitters: a standalone construct

One name. One construct. A landmark on the map.

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frequenthitters1 CONSTRUCTFrequent hittersROCHE · DRUG DISCOVERY

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Drug discovery

compounds that appear as hits across many unrelated screening assays, flagged as likely false positives.

In drug discovery, frequent hitters refers to compounds that appear as hits across many unrelated screening assays, flagged as likely false positives. This meaning comes from Roche (2001) in Journal of Medicinal Chemistry.[1]

Unit
Recovery means
Measured by

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Nearby constructs

screening3 fields · 4 citationsjingle · one word, three constructs

References

  1. Roche, O., Schneider, P., Zuegge, J., Guba, W., Kansy, M., Alanine, A., Bleicher, K., Danel, F., Gutknecht, E., Rogers-Evans, M., Neidhart, W., Stalder, H., Dillon, M., Sjögren, E., Fotouhi, N., Gillespie, P., Goodnow, R., Harris, W., Jones, P., Taniguchi, M., Tsujii, S., von der Saal, W., Zimmermann, G., & Schneider, G. (2001). Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries. Journal of Medicinal Chemistry, 45(1), 137-142. https://doi.org/10.1021/jm010934d

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