Construct · 1 fields · 1 citations

GalNAc conjugate: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
GalNAcconjugate1 CONSTRUCTGalNAc conjugateNAIR · DRUG DELIVERY

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Drug delivery

attachment of multivalent N-acetylgalactosamine to an oligonucleotide so it binds the asialoglycoprotein receptor and is taken up by liver cells.

In drug delivery, GalNAc conjugate refers to attachment of multivalent N-acetylgalactosamine to an oligonucleotide so it binds the asialoglycoprotein receptor and is taken up by liver cells. This meaning comes from Nair (2014) in Journal of the American Chemical Society.[1]

Unit
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Nearby constructs

attachment2 fields · 6 citationsjingle · one word, two constructsdelivery1 fields · 1 citationsanchor · a standalone constructreceptor2 fields · 2 citationsjingle · one word, two constructs

References

  1. Nair, J. K., Willoughby, J. L. S., Chan, A., Charisse, K., Alam, M. R., Wang, Q., Hoekstra, M., Kandasamy, P., Kel’in, A. V., Milstein, S., Taneja, N., O’Shea, J., Shaikh, S., Zhang, L., van der Sluis, R. J., Jung, M. E., Akinc, A., Hutabarat, R., Kuchimanchi, S., Fitzgerald, K., Zimmermann, T., van Berkel, T. J. C., Maier, M. A., Rajeev, K. G., & Manoharan, M. (2014). Multivalent N -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing. Journal of the American Chemical Society, 136(49), 16958-16961. https://doi.org/10.1021/ja505986a

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