Construct · 1 fields · 1 citations

gene mutational constraint: a standalone construct

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gene mutationalconstraint1 CONSTRUCTGene mutationalSAMOCHA · GENETICS AND

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Genetics and genomics

the depletion of observed variants in a gene relative to a mutation-rate model, used to flag genes under purifying selection.

In genetics and genomics, gene mutational constraint refers to the depletion of observed variants in a gene relative to a mutation-rate model, used to flag genes under purifying selection. This meaning comes from Samocha (2014) in Nature Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

de novo mutation enrichment framework1 fields · 1 citationsanchor · a standalone constructdepletion3 fields · 4 citationsjingle · one word, three constructsmodel3 fields · 3 citationsjingle · one word, three constructs

References

  1. Samocha, K. E., Robinson, E. B., Sanders, S. J., Stevens, C., Sabo, A., McGrath, L. M., Kosmicki, J. A., Rehnström, K., Mallick, S., Kirby, A., Wall, D. P., MacArthur, D. G., Gabriel, S. B., DePristo, M., Purcell, S. M., Palotie, A., Boerwinkle, E., Buxbaum, J. D., Cook, E. H., Gibbs, R. A., Schellenberg, G. D., Sutcliffe, J. S., Devlin, B., Roeder, K., Neale, B. M., & Daly, M. J. (2014). A framework for the interpretation of de novo mutation in human disease. Nature Genetics, 46(9), 944-950. https://doi.org/10.1038/ng.3050

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