Construct · 1 fields · 1 citations

group efficiency: a standalone construct

One name. One construct. A landmark on the map.

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A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Drug discovery

binding free energy gained per heavy atom added to a ligand, used to judge which added groups earn their size in hit-to-lead work.

In drug discovery, group efficiency refers to binding free energy gained per heavy atom added to a ligand, used to judge which added groups earn their size in hit-to-lead work. This meaning comes from Verdonk (2008) in ChemMedChem.[1]

Unit
Recovery means
Measured by

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs efficiency4 fields · 5 citationsjingle · one word, four constructs energy5 fields · 10 citationsjingle · one word, five constructs

References

Verdonk, M. L., & Rees, D. C. (2008). Group Efficiency: A Guideline for Hits‐to‐Leads Chemistry. ChemMedChem, 3(8), 1179-1180. https://doi.org/10.1002/cmdc.200800132

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