Construct · 1 fields · 1 citations

hapten: a standalone construct

One name. One construct. A landmark on the map.

● anchor · one construct, one field Nearest construct by meaning·not indexed
hapten1 CONSTRUCTHaptenLANDSTEINER · CARRIER

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Immunology

A small molecule that is antigenic only when attached

In immunology, a hapten is a small molecule that can be recognised by an antibody but cannot by itself provoke an immune response; it becomes immunogenic only when coupled to a larger carrier protein. Murphy and Weaver's Janeway's immunobiology describes how such small chemical groups, once bound to a carrier, elicit antibodies that then react with the hapten alone, a principle established by Landsteiner's studies of serological specificity. The referent is this class of small, bindable-but-not-immunogenic molecules, central to how fine antibody specificity and many drug and contact allergies are understood.[1]

Unit
Whether a small molecule can bind antibody and whether, once carrier-coupled, it elicits a response
Recovery means
Not applicable
Measured by
Shown by antibody binding to the free small molecule alongside a response only when it is conjugated to a carrier

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Nearby constructs

carrier3 fields · 3 citationsjingle · one word, three constructsclass3 fields · 3 citationsjingle · one word, three constructscontact2 fields · 3 citationsjingle · one word, two constructs

References

  1. Murphy, K., & Weaver, C. (2016). Janeway's immunobiology (9th ed.). Garland Science. ISBN 9780815345053

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