Construct · 1 fields · 1 citations

knobs-into-holes: a standalone construct

One name. One construct. A landmark on the map.

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Protein engineering

engineering antibody CH3 domains with a bulky residue on one chain and a matching cavity on the other so two different heavy chains pair.

In protein engineering, knobs-into-holes refers to engineering antibody CH3 domains with a bulky residue on one chain and a matching cavity on the other so two different heavy chains pair. This meaning comes from Ridgway (1996) in Protein Engineering.[1]

Unit
Recovery means
Measured by

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Nearby constructs

chain3 fields · 3 citationsjingle · one word, three constructs matching4 fields · 4 citationsjingle · one word, four constructs residue3 fields · 5 citationsjingle · one word, three constructs

References

Ridgway, J. B. B., Presta, L. G., & Carter, P. (1996). ‘Knobs-into-holes’ engineering of antibody C_H3 domains for heavy chain heterodimerization. Protein Engineering, 9(7), 617-621. https://doi.org/10.1093/protein/9.7.617

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