Construct · 1 fields · 1 citations

lead-likeness: a standalone construct

One name. One construct. A landmark on the map.

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Drug discovery

property profile suited to a starting lead, smaller and less lipophilic than a drug, leaving room for growth during optimization.

In drug discovery, lead-likeness refers to property profile suited to a starting lead, smaller and less lipophilic than a drug, leaving room for growth during optimization. This meaning comes from Oprea (2001) in Journal of Chemical Information and Computer Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

growth4 fields · 4 citationsjingle · one word, four constructs information4 fields · 5 citationsjingle · one word, four constructs profile2 fields · 2 citationsjingle · one word, two constructs

References

Oprea, T. I., Davis, A. M., Teague, S. J., & Leeson, P. D. (2001). Is There a Difference between Leads and Drugs? A Historical Perspective. Journal of Chemical Information and Computer Sciences, 41(5), 1308-1315. https://doi.org/10.1021/ci010366a

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