Construct · 1 fields · 1 citations

LOEUF: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
LOEUF1 CONSTRUCTLOEUFKARCZEWSKI · MEDICAL GENETICS

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Medical genetics

a gene-level metric of intolerance to loss-of-function variation, the upper confidence bound of observed over expected loss-of-function variants in population data.

In medical genetics, LOEUF refers to a gene-level metric of intolerance to loss-of-function variation, the upper confidence bound of observed over expected loss-of-function variants in population data. This meaning comes from Karczewski (2020) in Nature.[1]

Unit
Recovery means
Measured by

Next

Run it through the Collider, or take the citations with you.

See how LOEUF sits against neighbouring constructs in the Collider, or export every reference on this page in one click.

Open in ColliderExport BibTeXReport this entry

Nearby constructs

confidence4 fields · 5 citationsjingle · one word, four constructsmetric4 fields · 4 citationsjingle · one word, four constructspopulation4 fields · 4 citationsjingle · one word, four constructs

References

  1. Karczewski, K. J., Francioli, L. C., Tiao, G., Cummings, B. B., Alföldi, J., Wang, Q., Collins, R. L., Laricchia, K. M., Ganna, A., Birnbaum, D. P., Gauthier, L. D., Brand, H., Solomonson, M., Watts, N. A., Rhodes, D., Singer-Berk, M., England, E. M., Seaby, E. G., Kosmicki, J. A., Walters, R. K., Tashman, K., Farjoun, Y., Banks, E., Poterba, T., Wang, A., Seed, C., Whiffin, N., Chong, J. X., Samocha, K. E., Pierce-Hoffman, E., Zappala, Z., O’Donnell-Luria, A. H., Minikel, E. V., Weisburd, B., Lek, M., Ware, J. S., Vittal, C., Armean, I. M., Bergelson, L., Cibulskis, K., Connolly, K. M., Covarrubias, M., Donnelly, S., Ferriera, S., Gabriel, S., Gentry, J., Gupta, N., Jeandet, T., Kaplan, D., Llanwarne, C., Munshi, R., Novod, S., Petrillo, N., Roazen, D., Ruano-Rubio, V., Saltzman, A., Schleicher, M., Soto, J., Tibbetts, K., Tolonen, C., Wade, G., Talkowski, M. E., Genome Aggregation Database Consortium, Aguilar Salinas, C. A., Ahmad, T., Albert, C. M., Ardissino, D., Atzmon, G., Barnard, J., Beaugerie, L., Benjamin, E. J., Boehnke, M., Bonnycastle, L. L., Bottinger, E. P., Bowden, D. W., Bown, M. J., Chambers, J. C., Chan, J. C., Chasman, D., Cho, J., Chung, M. K., Cohen, B., Correa, A., Dabelea, D., Daly, M. J., Darbar, D., Duggirala, R., Dupuis, J., Ellinor, P. T., Elosua, R., Erdmann, J., Esko, T., Färkkilä, M., Florez, J., Franke, A., Getz, G., Glaser, B., Glatt, S. J., Goldstein, D., Gonzalez, C., Groop, L., Haiman, C., Hanis, C., Harms, M., Hiltunen, M., Holi, M. M., Hultman, C. M., Kallela, M., Kaprio, J., Kathiresan, S., Kim, B., Kim, Y. J., Kirov, G., Kooner, J., Koskinen, S., Krumholz, H. M., Kugathasan, S., Kwak, S. H., Laakso, M., Lehtimäki, T., Loos, R. J. F., Lubitz, S. A., Ma, R. C. W., MacArthur, D. G., Marrugat, J., Mattila, K. M., McCarroll, S., McCarthy, M. I., McGovern, D., McPherson, R., Meigs, J. B., Melander, O., Metspalu, A., Neale, B. M., Nilsson, P. M., O’Donovan, M. C., Ongur, D., Orozco, L., Owen, M. J., Palmer, C. N. A., Palotie, A., Park, K. S., Pato, C., Pulver, A. E., Rahman, N., Remes, A. M., Rioux, J. D., Ripatti, S., Roden, D. M., Saleheen, D., Salomaa, V., Samani, N. J., Scharf, J., Schunkert, H., Shoemaker, M. B., Sklar, P., Soininen, H., Sokol, H., Spector, T., Sullivan, P. F., Suvisaari, J., Tai, E. S., Teo, Y. Y., Tiinamaija, T., Tsuang, M., Turner, D., Tusie-Luna, T., Vartiainen, E., Vawter, M. P., Ware, J. S., Watkins, H., Weersma, R. K., Wessman, M., Wilson, J. G., Xavier, R. J., Neale, B. M., Daly, M. J., & MacArthur, D. G. (2020). The mutational constraint spectrum quantified from variation in 141,456 humans. Nature, 581(7809), 434-443. https://doi.org/10.1038/s41586-020-2308-7

Cited on this page?

Confirm your construct, or correct us.

If your work is cited behind one of these entries, you know better than we do whether we captured the meaning right. Confirm it, suggest an edit, or dispute it, and your name goes on the entry as an author who has checked it, linked to your ORCID.

Claim your construct