Construct · 1 fields · 1 citations

logic-gated chimeric antigen receptor: a standalone construct

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Immunology

splitting activation across two receptors so engineered T cells act only where both antigens appear together.

In immunology, logic-gated chimeric antigen receptor refers to splitting activation across two receptors so engineered T cells act only where both antigens appear together. This meaning comes from Kloss (2012) in Nature Biotechnology.[1]

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Nearby constructs

activation4 fields · 4 citationsjingle · one word, four constructs chimera2 fields · 4 citationsjingle · one word, two constructs receptor2 fields · 2 citationsjingle · one word, two constructs

References

Kloss, C. C., Condomines, M., Cartellieri, M., Bachmann, M., & Sadelain, M. (2012). Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells. Nature Biotechnology, 31(1), 71-75. https://doi.org/10.1038/nbt.2459

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