Construct · 1 fields · 1 citations

matched molecular pair analysis: a standalone construct

One name. One construct. A landmark on the map.

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matched molecularpair analysis1 CONSTRUCTMatched molecular pairLEACH · DRUG DISCOVERY

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Drug discovery

analysis of property changes between pairs of compounds that differ by a single structural transformation, used to guide optimization.

In drug discovery, matched molecular pair analysis refers to analysis of property changes between pairs of compounds that differ by a single structural transformation, used to guide optimization. This meaning comes from Leach (2006) in Journal of Medicinal Chemistry.[1]

Unit
Recovery means
Measured by

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Nearby constructs

property4 fields · 4 citationsjingle · one word, four constructsstructural transformation1 fields · 1 citationsanchor · a standalone constructtransformation5 fields · 5 citationsjingle · one word, five constructs

References

  1. Leach, A. G., Jones, H. D., Cosgrove, D. A., Kenny, P. W., Ruston, L., MacFaul, P., Wood, J. M., Colclough, N., & Law, B. (2006). Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure. Journal of Medicinal Chemistry, 49(23), 6672-6682. https://doi.org/10.1021/jm0605233

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