Construct · 1 fields · 1 citations

metabolic theory of dominance: a standalone construct

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Genetics

the explanation that most loss-of-function mutations are recessive because flux through metabolic pathways barely drops when one enzyme copy is lost.

In genetics, metabolic theory of dominance refers to the explanation that most loss-of-function mutations are recessive because flux through metabolic pathways barely drops when one enzyme copy is lost. This meaning comes from Kacser (1981) in Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

dominance4 fields · 4 citationsjingle · one word, four constructs flux3 fields · 3 citationsjingle · one word, three constructs

References

Kacser, H., & Burns, J. A. (1981). The Molecular Basis of Dominance. Genetics, 97(3-4), 639-666. https://doi.org/10.1093/genetics/97.3-4.639

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