Construct · 1 fields · 1 citations

metal hypothesis of Alzheimer's disease: a standalone construct

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Dementia research

the proposal that disturbed handling of zinc, copper and iron in the brain promotes amyloid beta aggregation and oxidative injury in Alzheimer's disease.

In dementia research, metal hypothesis of Alzheimer's disease refers to the proposal that disturbed handling of zinc, copper and iron in the brain promotes amyloid beta aggregation and oxidative injury in Alzheimer's disease. This meaning comes from Bush (2008) in Neurotherapeutics.[1]

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Nearby constructs

beta3 fields · 3 citationsjingle · one word, three constructs hypothesis2 fields · 2 citationsjingle · one word, two constructs injury2 fields · 2 citationsjingle · one word, two carriers

References

Bush, A. I., & Tanzi, R. E. (2008). Therapeutics for Alzheimer's Disease Based on the Metal Hypothesis. Neurotherapeutics, 5(3), 421-432. https://doi.org/10.1016/j.nurt.2008.05.001

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