Construct · 1 fields · 1 citations

misfolding avoidance hypothesis: a standalone construct

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Biochemistry

the proposal that highly expressed proteins evolve slowly because selection against the toxicity of mistranslated, misfolded copies constrains their sequences.

In biochemistry, misfolding avoidance hypothesis refers to the proposal that highly expressed proteins evolve slowly because selection against the toxicity of mistranslated, misfolded copies constrains their sequences. This meaning comes from Drummond (2008) in Cell.[1]

Unit
Recovery means
Measured by

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Nearby constructs

avoidance2 fields · 3 citationsjingle · one word, two carriers cell2 fields · 3 citationsjingle · one word, two constructs hypothesis2 fields · 2 citationsjingle · one word, two constructs

References

Drummond, D. A., & Wilke, C. O. (2008). Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution. Cell, 134(2), 341-352. https://doi.org/10.1016/j.cell.2008.05.042

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