Construct · 1 fields · 1 citations

neurotoxic reactive astrocytes: a standalone construct

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Neuroimmunology

a reactive astrocyte state induced by cytokines from activated microglia, which loses supportive functions and kills neurons and oligodendrocytes.

In neuroimmunology, neurotoxic reactive astrocytes refers to a reactive astrocyte state induced by cytokines from activated microglia, which loses supportive functions and kills neurons and oligodendrocytes. This meaning comes from Liddelow (2017) in Nature.[1]

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state4 fields · 6 citationsjingle · one word, four constructs

References

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V. L., Dawson, T. M., Stevens, B., & Barres, B. A. (2017). Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 541(7638), 481-487. https://doi.org/10.1038/nature21029

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