Construct · 1 fields · 1 citations

pharmacological chaperone: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

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Pharmacology

a small molecule that binds a misfolded protein, stabilizes its folding and restores its correct trafficking and function in the cell.

In pharmacology, pharmacological chaperone refers to a small molecule that binds a misfolded protein, stabilizes its folding and restores its correct trafficking and function in the cell. This meaning comes from Morello (2000) in Journal of Clinical Investigation.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs chaperone1 fields · 1 citationsanchor · a standalone construct function5 fields · 6 citationsjingle · one word, five constructs

References

Morello, J., Salahpour, A., Laperrière, A., Bernier, V., Arthus, M., Lonergan, M., Petäjä-Repo, U., Angers, S., Morin, D., Bichet, D. G., & Bouvier, M. (2000). Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. Journal of Clinical Investigation, 105(7), 887-895. https://doi.org/10.1172/jci8688

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