Construct · 1 fields · 1 citations

polymerase: a standalone construct

One name. One construct. A landmark on the map.

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polymerase1 CONSTRUCTPolymeraseLEHMAN ET AL. · 1958

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Molecular biology

An enzyme that builds a nucleic-acid chain

In molecular biology, a polymerase is an enzyme that synthesises a nucleic-acid chain by adding nucleotides one at a time to a growing strand, copying the sequence of a template, as DNA polymerase does in replication and RNA polymerase in transcription. Lehman, Bessman, Simms, and Kornberg's 1958 Enzymatic synthesis of deoxyribonucleic acid reported the isolation of the first DNA polymerase from Escherichia coli. The referent is a template-directed synthesising enzyme defined by the strand it builds and the template it reads, characterised by its rate, fidelity, and processivity.[1]

Unit
The rate, fidelity, and processivity with which nucleotides are added to the growing strand
Recovery means
Not applicable
Measured by
Assayed by nucleotide incorporation into the new strand, the error rate per base added, and the length synthesised per binding event

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Nearby constructs

replication4 fields · 4 citationsjingle · one word, four constructstranscription2 fields · 2 citationsjingle · one word, two constructsamplification4 fields · 4 citationsjingle · one word, four constructs

References

  1. Lehman, I. R., Bessman, M. J., Simms, E. S., & Kornberg, A. (1958). Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli. Journal of Biological Chemistry, 233(1), 163–170. https://doi.org/10.1016/s0021-9258(19)68048-8

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