Construct · 1 fields · 1 citations

principle of minimal frustration: a standalone construct

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Structural biology

the idea that natural protein sequences evolved so that native contacts conflict as little as possible, giving a smooth, funnel-like route to the folded state.

In structural biology, principle of minimal frustration refers to the idea that natural protein sequences evolved so that native contacts conflict as little as possible, giving a smooth, funnel-like route to the folded state. This meaning comes from Bryngelson (1987) in Proceedings of the National Academy of Sciences.[1]

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Nearby constructs

conflict4 fields · 5 citationsjingle · one word, four constructs frustration3 fields · 7 citationsjingle · one word, three constructs natural3 fields · 7 citationsjingle · one word, three constructs

References

Bryngelson, J. D., & Wolynes, P. G. (1987). Spin glasses and the statistical mechanics of protein folding. Proceedings of the National Academy of Sciences, 84(21), 7524-7528. https://doi.org/10.1073/pnas.84.21.7524

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