Construct · 1 fields · 1 citations

proteostasis collapse: a standalone construct

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Biochemistry

an early, abrupt decline in the cell's ability to keep proteins folded and functional, proposed as a driver of aging.

In biochemistry, proteostasis collapse refers to an early, abrupt decline in the cell's ability to keep proteins folded and functional, proposed as a driver of aging. This meaning comes from Ben-Zvi (2009) in Proceedings of the National Academy of Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

aging4 fields · 5 citationsjingle · one word, four constructs cell2 fields · 3 citationsjingle · one word, two constructs collapse4 fields · 5 citationsjingle · one word, four constructs

References

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009). Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proceedings of the National Academy of Sciences, 106(35), 14914-14919. https://doi.org/10.1073/pnas.0902882106

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