Construct · 1 fields · 1 citations

proton sponge hypothesis: a standalone construct

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Drug delivery

proposal that buffering polymers such as polyethylenimine absorb protons in endosomes, causing swelling and rupture that releases their cargo.

In drug delivery, proton sponge hypothesis refers to proposal that buffering polymers such as polyethylenimine absorb protons in endosomes, causing swelling and rupture that releases their cargo. This meaning comes from Boussif (1995) in Proceedings of the National Academy of Sciences.[1]

Unit
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Nearby constructs

delivery1 fields · 1 citationsanchor · a standalone construct hypothesis2 fields · 2 citationsjingle · one word, two constructs rupture4 fields · 5 citationsjingle · one word, four constructs

References

Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., & Behr, J. P. (1995). A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proceedings of the National Academy of Sciences, 92(16), 7297-7301. https://doi.org/10.1073/pnas.92.16.7297

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