Construct · 1 fields · 1 citations

senolytic: a standalone construct

One name. One construct. A landmark on the map.

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senolytic1 CONSTRUCTSenolytic (Biology)ZHU · BIOLOGY OF AGING

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Biology of aging

drugs that selectively kill senescent cells by disabling the pro-survival pathways those cells depend on.

In biology of aging, senolytic refers to drugs that selectively kill senescent cells by disabling the pro-survival pathways those cells depend on. This meaning comes from Zhu (2015) in Aging Cell.[1]

Unit
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Nearby constructs

aging4 fields · 5 citationsjingle · one word, four constructscell2 fields · 3 citationsjingle · one word, two constructs

References

  1. Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., LaRusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B., McGowan, S. J., Fuhrmann‐Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J., & Kirkland, J. L. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell, 14(4), 644-658. https://doi.org/10.1111/acel.12344

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