Construct · 1 fields · 1 citations

Sherman paradox: a standalone construct

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Medical genetics

the observation that fragile X risk rises across generations of a pedigree, so grandsons of transmitting males are affected more often than their brothers.

In medical genetics, Sherman paradox refers to the observation that fragile X risk rises across generations of a pedigree, so grandsons of transmitting males are affected more often than their brothers. This meaning comes from Fu (1991) in Cell.[1]

Unit
Recovery means
Measured by

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs observation2 fields · 2 citationsjingle · one word, two constructs paradox3 fields · 4 citationsjingle · one word, three constructs

References

Fu, Y., Kuhl, D. P. A., Pizzuti, A., Pieretti, M., Sutcliffe, J. S., Richards, S., Verkert, A. J. M. H., Holden, J. J. A., Fenwick, R. G., Warren, S. T., Oostra, B. A., Nelson, D. L., & Caskey, C. T. (1991). Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox. Cell, 67(6), 1047-1058. https://doi.org/10.1016/0092-8674(91)90283-5

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