Construct · 1 fields · 1 citations

single-chain variable fragment: a standalone construct

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Immunology

antibody binding site reduced to one polypeptide by linking the heavy and light variable domains.

In immunology, single-chain variable fragment refers to antibody binding site reduced to one polypeptide by linking the heavy and light variable domains. This meaning comes from Huston (1988) in Proceedings of the National Academy of Sciences.[1]

Unit
Recovery means
Measured by

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs variable4 fields · 4 citationsjingle · one word, four constructs

References

Huston, J. S., Levinson, D., Mudgett-Hunter, M., Tai, M. S., Novotný, J., Margolies, M. N., Ridge, R. J., Bruccoleri, R. E., Haber, E., & Crea, R. (1988). Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proceedings of the National Academy of Sciences, 85(16), 5879-5883. https://doi.org/10.1073/pnas.85.16.5879

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