Construct · 1 fields · 1 citations

synaptic failure hypothesis: a standalone construct

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Neuroscience

proposal that Alzheimer's disease begins as subtle failure of synaptic function, caused by soluble amyloid, well before neurons die.

In neuroscience, synaptic failure hypothesis refers to proposal that Alzheimer's disease begins as subtle failure of synaptic function, caused by soluble amyloid, well before neurons die. This meaning comes from Selkoe (2002) in Science.[1]

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Nearby constructs

failure4 fields · 6 citationsjingle · one word, four constructs function5 fields · 6 citationsjingle · one word, five constructs hypothesis2 fields · 2 citationsjingle · one word, two constructs

References

Selkoe, D. J. (2002). Alzheimer's Disease Is a Synaptic Failure. Science, 298(5594), 789-791. https://doi.org/10.1126/science.1074069

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