Construct · 1 fields · 1 citations

T cell exhaustion: a standalone construct

One name. One construct. A landmark on the map.

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T cellexhaustion1 CONSTRUCTT cell exhaustionZAJAC · IMMUNOLOGY

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Immunology

a state of progressive loss of effector function in T cells that persist during chronic infection or cancer despite ongoing antigen exposure.

In immunology, T cell exhaustion refers to a state of progressive loss of effector function in T cells that persist during chronic infection or cancer despite ongoing antigen exposure. This meaning comes from Zajac (1998) in The Journal of Experimental Medicine.[1]

Unit
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Measured by

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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructseffector2 fields · 2 citationsjingle · one word, two constructsexhaustion3 fields · 3 citationsjingle · one word, three constructs

References

  1. Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998). Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function. The Journal of Experimental Medicine, 188(12), 2205-2213. https://doi.org/10.1084/jem.188.12.2205

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