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toxic oligomer hypothesis: a standalone construct

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toxic oligomerhypothesis1 CONSTRUCTToxic oligomerHAASS · DEMENTIA RESEARCH

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Dementia research

the proposal that small soluble aggregates of misfolded proteins such as amyloid beta, rather than large insoluble plaques, are the main agents that injure synapses in neurodegeneration.

In dementia research, toxic oligomer hypothesis refers to the proposal that small soluble aggregates of misfolded proteins such as amyloid beta, rather than large insoluble plaques, are the main agents that injure synapses in neurodegeneration. This meaning comes from Haass (2007) in Nature Reviews Molecular Cell Biology.[1]

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beta3 fields · 3 citationsjingle · one word, three constructscell2 fields · 3 citationsjingle · one word, two constructshypothesis2 fields · 2 citationsjingle · one word, two constructs

References

  1. Haass, C., & Selkoe, D. J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide. Nature Reviews Molecular Cell Biology, 8(2), 101-112. https://doi.org/10.1038/nrm2101

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