Construct · 1 fields · 1 citations

two-hit hypothesis: a standalone construct

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Cancer biology

the proposal that some cancers need two mutational events in the same cell, one of which may be inherited.

In cancer biology, two-hit hypothesis refers to the proposal that some cancers need two mutational events in the same cell, one of which may be inherited. This meaning comes from Knudson (1971) in Proceedings of the National Academy of Sciences.[1]

Unit
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Nearby constructs

cell2 fields · 3 citationsjingle · one word, two constructs hypothesis2 fields · 2 citationsjingle · one word, two constructs need3 fields · 4 citationsjingle · one word, three constructs

References

Knudson, A. G. (1971). Mutation and Cancer: Statistical Study of Retinoblastoma. Proceedings of the National Academy of Sciences, 68(4), 820-823. https://doi.org/10.1073/pnas.68.4.820

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