Construct · 1 fields · 1 citations

unbound brain-to-plasma partition coefficient: a standalone construct

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Pharmacokinetics

ratio of unbound drug concentration in brain to that in plasma at steady state, measuring the extent of net drug transport across the blood-brain barrier.

In pharmacokinetics, unbound brain-to-plasma partition coefficient refers to ratio of unbound drug concentration in brain to that in plasma at steady state, measuring the extent of net drug transport across the blood-brain barrier. This meaning comes from Hammarlund-Udenaes (2007) in Pharmaceutical Research.[1]

Unit
Recovery means
Measured by

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Nearby constructs

barrier4 fields · 7 citationsjingle · one word, four constructs blood-brain barrier1 fields · 4 citationsanchor · a standalone construct concentration4 fields · 4 citationsjingle · one word, four constructs

References

Hammarlund-Udenaes, M., Fridén, M., Syvänen, S., & Gupta, A. (2007). On The Rate and Extent of Drug Delivery to the Brain. Pharmaceutical Research, 25(8), 1737-1750. https://doi.org/10.1007/s11095-007-9502-2

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