Construct · 1 fields · 1 citations

within-family GWAS: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed
within-familyGWAS1 CONSTRUCTWithin-family GWASHOWE · GENETIC EPIDEMIOLOGY

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Genetic epidemiology

a genome-wide association study comparing siblings, which separates direct genetic effects from stratification, assortative mating and indirect parental effects.

In genetic epidemiology, within-family GWAS refers to a genome-wide association study comparing siblings, which separates direct genetic effects from stratification, assortative mating and indirect parental effects. This meaning comes from Howe (2022) in Nature Genetics.[1]

Unit
Recovery means
Measured by

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Nearby constructs

association4 fields · 4 citationsjingle · one word, four constructsgenome-wide association study1 fields · 1 citationsanchor · a standalone constructhomogamy2 fields · 2 citationsinvariant · one construct, two fields

References

  1. Howe, L. J., Nivard, M. G., Morris, T. T., Hansen, A. F., Rasheed, H., Cho, Y., Chittoor, G., Ahlskog, R., Lind, P. A., Palviainen, T., van der Zee, M. D., Cheesman, R., Mangino, M., Wang, Y., Li, S., Klaric, L., Ratliff, S. M., Bielak, L. F., Nygaard, M., Giannelis, A., Willoughby, E. A., Reynolds, C. A., Balbona, J. V., Andreassen, O. A., Ask, H., Baras, A., Bauer, C. R., Boomsma, D. I., Campbell, A., Campbell, H., Chen, Z., Christofidou, P., Corfield, E., Dahm, C. C., Dokuru, D. R., Evans, L. M., de Geus, E. J. C., Giddaluru, S., Gordon, S. D., Harden, K. P., Hill, W. D., Hughes, A., Kerr, S. M., Kim, Y., Kweon, H., Latvala, A., Lawlor, D. A., Li, L., Lin, K., Magnus, P., Magnusson, P. K. E., Mallard, T. T., Martikainen, P., Mills, M. C., Njølstad, P. R., Overton, J. D., Pedersen, N. L., Porteous, D. J., Reid, J., Silventoinen, K., Southey, M. C., Stoltenberg, C., Tucker-Drob, E. M., Wright, M. J., Social Science Genetic Association Consortium, Kweon, H., Koellinger, P. D., Benjamin, D. J., Turley, P., Within Family Consortium, Howe, L. J., Nivard, M. G., Morris, T. T., Hansen, A. F., Rasheed, H., Cho, Y., Chittoor, G., Ahlskog, R., Lind, P. A., Palviainen, T., van der Zee, M. D., Cheesman, R., Mangino, M., Wang, Y., Li, S., Klaric, L., Ratliff, S. M., Bielak, L. F., Nygaard, M., Giannelis, A., Willoughby, E. A., Reynolds, C. A., Balbona, J. V., Andreassen, O. A., Ask, H., Boomsma, D. I., Campbell, A., Campbell, H., Chen, Z., Christofidou, P., Corfield, E., Dahm, C. C., Dokuru, D. R., Evans, L. M., de Geus, E. J. C., Giddaluru, S., Gordon, S. D., Harden, K. P., Hill, W. D., Hughes, A., Kerr, S. M., Kim, Y., Latvala, A., Lawlor, D. A., Li, L., Lin, K., Magnus, P., Magnusson, P. K. E., Mallard, T. T., Martikainen, P., Mills, M. C., Njølstad, P. R., Pedersen, N. L., Porteous, D. J., Silventoinen, K., Southey, M. C., Stoltenberg, C., Tucker-Drob, E. M., Wright, M. J., Hewitt, J. K., Keller, M. C., Stallings, M. C., Lee, J. J., Christensen, K., Kardia, S. L. R., Peyser, P. A., Smith, J. A., Wilson, J. F., Hopper, J. L., Hägg, S., Spector, T. D., Pingault, J., Plomin, R., Havdahl, A., Bartels, M., Martin, N. G., Oskarsson, S., Justice, A. E., Millwood, I. Y., Hveem, K., Naess, Ø., Willer, C. J., Åsvold, B. O., Kaprio, J., Medland, S. E., Walters, R. G., Evans, D. M., Smith, G. D., Hayward, C., Brumpton, B., Hemani, G., Davies, N. M., Hewitt, J. K., Keller, M. C., Stallings, M. C., Lee, J. J., Christensen, K., Kardia, S. L. R., Peyser, P. A., Smith, J. A., Wilson, J. F., Hopper, J. L., Hägg, S., Spector, T. D., Pingault, J., Plomin, R., Havdahl, A., Bartels, M., Martin, N. G., Oskarsson, S., Justice, A. E., Millwood, I. Y., Hveem, K., Naess, Ø., Willer, C. J., Åsvold, B. O., Koellinger, P. D., Kaprio, J., Medland, S. E., Walters, R. G., Benjamin, D. J., Turley, P., Evans, D. M., Davey Smith, G., Hayward, C., Brumpton, B., Hemani, G., & Davies, N. M. (2022). Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects. Nature Genetics, 54(5), 581-592. https://doi.org/10.1038/s41588-022-01062-7

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