Construct · 1 fields · 1 citations

4/400 rule: a standalone construct

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Medicinal chemistry

guideline that compounds with molecular weight under 400 and logP under 4 tend to have more favorable absorption, distribution, metabolism and excretion profiles.

In medicinal chemistry, 4/400 rule refers to guideline that compounds with molecular weight under 400 and logP under 4 tend to have more favorable absorption, distribution, metabolism and excretion profiles. This meaning comes from Gleeson (2008) in Journal of Medicinal Chemistry.[1]

Unit
Recovery means
Measured by

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Nearby constructs

absorption6 fields · 6 citationsjingle · one word, six constructs distribution2 fields · 2 citationsjingle · one word, two constructs metabolism3 fields · 3 citationsjingle · one word, three constructs

References

Gleeson, M. P. (2008). Generation of a Set of Simple, Interpretable ADMET Rules of Thumb. Journal of Medicinal Chemistry, 51(4), 817-834. https://doi.org/10.1021/jm701122q

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