Construct · 1 fields · 1 citations

afucosylation: a standalone construct

One name. One construct. A landmark on the map.

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Biopharmaceutical development

absence of core fucose on an antibody glycan, which strongly raises binding to the Fc gamma receptor and cell killing.

In biopharmaceutical development, afucosylation refers to absence of core fucose on an antibody glycan, which strongly raises binding to the Fc gamma receptor and cell killing. This meaning comes from Shields (2002) in Journal of Biological Chemistry.[1]

Unit
Recovery means
Measured by

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Nearby constructs

binding4 fields · 4 citationsjingle · one word, four constructs cell2 fields · 3 citationsjingle · one word, two constructs development1 fields · 2 citationsanchor · a standalone construct

References

Shields, R. L., Lai, J., Keck, R., O'Connell, L. Y., Hong, K., Meng, Y. G., Weikert, S. H. A., & Presta, L. G. (2002). Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity. Journal of Biological Chemistry, 277(30), 26733-26740. https://doi.org/10.1074/jbc.m202069200

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