Construct · 1 fields · 3 citations

agonist: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaningantagonistcompare the meanings
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agonist1 CONSTRUCTReceptor agonistARIËNS · ACTIVATOR

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Pharmacology

A molecule that activates a receptor

In pharmacology, an agonist is a molecule that binds a receptor and switches it on, producing the cell's response, as opposed to a blocker that occupies the receptor without activating it. Ariëns's 1954 account of affinity and intrinsic activity gave an early quantitative frame separating a compound's tendency to bind from its power to produce an effect, and the International Union of Pharmacology's 2003 nomenclature together with Kenakin's 2004 review fixed the modern definitions of full, partial, and inverse agonists. The referent is a chemical that activates a biological receptor, graded by how strongly it drives the response, and it has nothing to do with a prime-mover muscle or a figure in a drama.[1][2][3]

Unit
A single compound acting at a receptor, scaled by its efficacy and potency
Recovery means
Not applicable
Measured by
Quantified by dose-response curves giving the concentration for half-maximal effect and the maximal response

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Nearby constructs

muscle1 fields · 1 citationsanchor · a standalone constructantagonist1 fields · 3 citationsanchor · a standalone constructefficacy4 fields · 4 citationsjingle · one word, four constructs

References

  1. Ariëns, E. J. (1954). Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. Archives Internationales de Pharmacodynamie et de Thérapie, 99(1), 32–49.
  2. Neubig, R. R., Spedding, M., Kenakin, T., & Christopoulos, A. (2003). International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology. Pharmacological Reviews, 55(4), 597–606. https://doi.org/10.1124/pr.55.4.4
  3. Kenakin, T. (2004). Principles: Receptor theory in pharmacology. Trends in Pharmacological Sciences, 25(4), 186–192. https://doi.org/10.1016/j.tips.2004.02.012

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