Construct · 1 fields · 1 citations

allostery: a standalone construct

One name. One construct. A landmark on the map.

● anchor · regulation at a second site Nearest construct by meaning·not indexed
allostery1 CONSTRUCTAllosteryMONOD ET AL. · 1965

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

Biochemistry & pharmacology

Binding at one site changes activity at another

Allostery is the regulation of a protein's activity by a molecule binding at a site distinct from its active or orthosteric site, so that binding at one location changes the protein's shape and its function elsewhere. Monod, Wyman, and Changeux's 1965 model explained such effects through a protein held in equilibrium between tense and relaxed conformations whose balance ligands shift. The referent is action-at-a-distance within a macromolecule, the basis of cooperative binding and of allosteric drugs that tune rather than switch a receptor.[1]

Unit
The change in activity at one site caused by binding at a separate site
Recovery means
Not applicable
Measured by
Inferred from cooperativity (e.g., Hill coefficients) and shifts in affinity or activity caused by allosteric ligands

Next

Run it through the Collider, or take the citations with you.

See how allostery sits against neighbouring constructs in the Collider, or export every reference on this page in one click.

Open in ColliderExport BibTeXReport this entry

Nearby constructs

ligand2 fields · 2 citationsinvariant · one construct, two systemscooperativity3 fields · 3 citationsinvariant · one construct, three systemseffector2 fields · 2 citationsjingle · one word, two constructs

References

  1. Monod, J., Wyman, J., & Changeux, J.-P. (1965). On the nature of allosteric transitions: A plausible model. Journal of Molecular Biology, 12(1), 88–118. https://doi.org/10.1016/S0022-2836(65)80285-6

Cited on this page?

Confirm your construct, or correct us.

If your work is cited behind one of these entries, you know better than we do whether we captured the meaning right. Confirm it, suggest an edit, or dispute it, and your name goes on the entry as an author who has checked it, linked to your ORCID.

Claim your construct