Construct · 1 fields · 1 citations

antigen escape: a standalone construct

One name. One construct. A landmark on the map.

● anchor · a standalone construct Nearest construct by meaning·not indexed

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Oncology

tumor relapse driven by loss or downregulation of the target antigen of a targeted immunotherapy such as CAR T cells.

In oncology, antigen escape refers to tumor relapse driven by loss or downregulation of the target antigen of a targeted immunotherapy such as CAR T cells. This meaning comes from Majzner (2018) in Cancer Discovery.[1]

Unit
Recovery means
Measured by

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Nearby constructs

downregulation1 fields · 1 citationsanchor · receptors lost on stimulation, one field escape2 fields · 2 citationsjingle · one word, two constructs loss2 fields · 3 citationsjingle · one word, two constructs

References

Majzner, R. G., & Mackall, C. L. (2018). Tumor Antigen Escape from CAR T-cell Therapy. Cancer Discovery, 8(10), 1219-1226. https://doi.org/10.1158/2159-8290.cd-18-0442

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