Construct · 1 fields · 1 citations

antisense-mediated exon skipping: a standalone construct

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antisense-mediatedexon skipping1 CONSTRUCTAntisense-mediated exonDOMINSKI · RNA BIOLOGY

A single standalone construct; nearby constructs are located against it in the Collider. Tap a field for its definition, unit, and measures.

RNA biology

use of a short complementary oligonucleotide to block a splice signal and redirect which exons are kept.

In RNA biology, antisense-mediated exon skipping refers to use of a short complementary oligonucleotide to block a splice signal and redirect which exons are kept. This meaning comes from Dominski (1993) in Proceedings of the National Academy of Sciences.[1]

Unit
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Measured by

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Nearby constructs

skip4 fields · 4 citationsjingle · one word, four constructsblock3 fields · 6 citationsjingle · one word, three constructsshort3 fields · 4 citationsjingle · one word, three constructs

References

  1. Dominski, Z., & Kole, R. (1993). Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides. Proceedings of the National Academy of Sciences, 90(18), 8673-8677. https://doi.org/10.1073/pnas.90.18.8673

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