Construct · 1 fields · 1 citations

beyond rule of five: a standalone construct

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beyond ruleof five1 CONSTRUCTBeyond rule of fiveDOAK · MEDICINAL CHEMISTRY

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Medicinal chemistry

chemical space of orally bioavailable drugs that exceed one or more of the rule-of-five limits, such as macrocycles and large natural products.

In medicinal chemistry, beyond rule of five refers to chemical space of orally bioavailable drugs that exceed one or more of the rule-of-five limits, such as macrocycles and large natural products. This meaning comes from Doak (2014) in Chemistry & Biology.[1]

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Nearby constructs

chemical space1 fields · 1 citationsanchor · a standalone constructLipinski's rule of five1 fields · 1 citationsanchor · a standalone constructnatural3 fields · 7 citationsjingle · one word, three constructs

References

  1. Doak, B. C., Over, B., Giordanetto, F., & Kihlberg, J. (2014). Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates. Chemistry & Biology, 21(9), 1115-1142. https://doi.org/10.1016/j.chembiol.2014.08.013

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